Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia

Brad P. Brayfield; Saul Phiri; Chipepo Kankasa; Jubra Muyanga; Hamakwa Mantina; Geoffrey Kwenda; John T. West; Ganapati Bhat; Dave B. Marx; Winslow Klaskala; Charles D. Mitchell; Charles Wood

doi:10.1086/367985

Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia

Brad P. Brayfield, Saul Phiri, Chipepo Kankasa, Jubra Muyanga, Hamakwa Mantina, Geoffrey Kwenda, John T. West, Ganapati Bhat, Dave B. Marx, Winslow Klaskala, Charles D. Mitchell, Charles Wood

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8-positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes.

Original language	English (US)
Pages (from-to)	559-568
Number of pages	10
Journal	Journal of Infectious Diseases
Volume	187
Issue number	4
DOIs	https://doi.org/10.1086/367985
State	Published - Feb 15 2003

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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title = "Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia",

abstract = "The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8-positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes.",

author = "Brayfield, {Brad P.} and Saul Phiri and Chipepo Kankasa and Jubra Muyanga and Hamakwa Mantina and Geoffrey Kwenda and West, {John T.} and Ganapati Bhat and Marx, {Dave B.} and Winslow Klaskala and Mitchell, {Charles D.} and Charles Wood",

note = "Funding Information: Financial support: Public Health Service (grants CA75903 and CA76958); Fogarty International Training and the Fogarty International Fellowship (grant TW01492 to S.P., J.M. and G.K.); National Center for Research Resources, Center of Biomedical Research Excellence (grant RR 15635 to C.W.).",

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doi = "10.1086/367985",

language = "English (US)",

volume = "187",

pages = "559--568",

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T1 - Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia

AU - Brayfield, Brad P.

AU - Phiri, Saul

AU - Kankasa, Chipepo

AU - Muyanga, Jubra

AU - Mantina, Hamakwa

AU - Kwenda, Geoffrey

AU - West, John T.

AU - Bhat, Ganapati

AU - Marx, Dave B.

AU - Klaskala, Winslow

AU - Mitchell, Charles D.

AU - Wood, Charles

N1 - Funding Information: Financial support: Public Health Service (grants CA75903 and CA76958); Fogarty International Training and the Fogarty International Fellowship (grant TW01492 to S.P., J.M. and G.K.); National Center for Research Resources, Center of Biomedical Research Excellence (grant RR 15635 to C.W.).

PY - 2003/2/15

Y1 - 2003/2/15

N2 - The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8-positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes.

AB - The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8-positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes.

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Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia

Abstract

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