Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia

Brad P. Brayfield, Saul Phiri, Chipepo Kankasa, Jubra Muyanga, Hamakwa Mantina, Geoffrey Kwenda, John T. West, Ganapati Bhat, Dave B. Marx, Winslow Klaskala, Charles D. Mitchell, Charles Wood

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8-positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes.

Original languageEnglish (US)
Pages (from-to)559-568
Number of pages10
JournalJournal of Infectious Diseases
Volume187
Issue number4
DOIs
StatePublished - Feb 15 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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