Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery

Yan Wang; Ying Xie; David Oupický

doi:10.1007/s40495-015-0044-8

Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery

Yan Wang, Ying Xie, David Oupický

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types of CXCR4-binding ligands used in targeting applications. Drug delivery applications that take advantage of CXCR4 inhibition to achieve enhanced anticancer and antimetastatic activity of combination treatments are also discussed.

Original language	English (US)
Journal	Current Pharmacology Reports
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/s40495-015-0044-8
State	Published - Feb 1 2016

Keywords

CXCR4
Cancer
Drug delivery
Gene delivery
Metastasis
Nanoparticles
siRNA delivery

ASJC Scopus subject areas

Biochemistry
Genetics
Pharmacology
Drug Discovery

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10.1007/s40495-015-0044-8

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title = "Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery",

abstract = "This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types of CXCR4-binding ligands used in targeting applications. Drug delivery applications that take advantage of CXCR4 inhibition to achieve enhanced anticancer and antimetastatic activity of combination treatments are also discussed.",

keywords = "CXCR4, Cancer, Drug delivery, Gene delivery, Metastasis, Nanoparticles, siRNA delivery",

author = "Yan Wang and Ying Xie and David Oupick{\'y}",

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T1 - Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery

AU - Wang, Yan

AU - Xie, Ying

AU - Oupický, David

PY - 2016/2/1

Y1 - 2016/2/1

N2 - This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types of CXCR4-binding ligands used in targeting applications. Drug delivery applications that take advantage of CXCR4 inhibition to achieve enhanced anticancer and antimetastatic activity of combination treatments are also discussed.

AB - This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types of CXCR4-binding ligands used in targeting applications. Drug delivery applications that take advantage of CXCR4 inhibition to achieve enhanced anticancer and antimetastatic activity of combination treatments are also discussed.

KW - CXCR4

KW - Cancer

KW - Drug delivery

KW - Gene delivery

KW - Metastasis

KW - Nanoparticles

KW - siRNA delivery

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DO - 10.1007/s40495-015-0044-8

M3 - Review article

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AN - SCOPUS:84993941069

SN - 2198-641X

VL - 2

JO - Current Pharmacology Reports

JF - Current Pharmacology Reports

IS - 1

ER -

Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery

Abstract

Keywords

ASJC Scopus subject areas

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