Potential of urinary metabolites for diagnosing multiple sclerosis

Teklab Gebregiworgis, Chandirasegaran Massilamany, Arunakumar Gangaplara, Sivasubramani Thulasingam, Venkata Kolli, Mark T. Werth, Eric D. Dodds, David Steffen, Jay Reddy, Robert Powers

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A definitive diagnostic test for multiple sclerosis (MS) does not exist; instead physicians use a combination of medical history, magnetic resonance imaging, and cerebrospinal fluid analysis (CSF). Significant effort has been employed to identify biomarkers from CSF to facilitate MS diagnosis; however, none of the proposed biomarkers have been successful to date. Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Nevertheless, urinary metabolites have not been extensively explored as a source of biomarkers for MS. We demonstrate that urinary metabolites have significant promise for monitoring disease-progression, and response to treatment in MS patients. NMR analysis of urine permitted the identification of metabolites that differentiate experimental autoimmune encephalomyelitis (EAE)-mice (prototypic disease model for MS) from healthy and MS drug-treated EAE mice.

Original languageEnglish (US)
Pages (from-to)684-690
Number of pages7
JournalACS chemical biology
Issue number4
StatePublished - Apr 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine


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