Potential role of lampalizumab for treatment of geographic atrophy

William Rhoades; Drew Dickson; Diana V. Do

doi:10.2147/OPTH.S59725

Potential role of lampalizumab for treatment of geographic atrophy

William Rhoades, Drew Dickson, Diana V. Do

Ophthalmology and Visual Sciences

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial.

Original language	English (US)
Pages (from-to)	1049-1056
Number of pages	8
Journal	Clinical Ophthalmology
Volume	9
DOIs	https://doi.org/10.2147/OPTH.S59725
State	Published - Jun 11 2015

Keywords

AMD
Age-related macular degeneration
Complement inhibition

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.2147/OPTH.S59725

Cite this

@article{c599e537cabf4231b92ae5271945290b,

title = "Potential role of lampalizumab for treatment of geographic atrophy",

abstract = "The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial.",

keywords = "AMD, Age-related macular degeneration, Complement inhibition",

author = "William Rhoades and Drew Dickson and Do, {Diana V.}",

note = "Publisher Copyright: {\textcopyright} 2015 Rhoades et al.",

year = "2015",

month = jun,

day = "11",

doi = "10.2147/OPTH.S59725",

language = "English (US)",

volume = "9",

pages = "1049--1056",

journal = "Clinical Ophthalmology",

issn = "1177-5467",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Potential role of lampalizumab for treatment of geographic atrophy

AU - Rhoades, William

AU - Dickson, Drew

AU - Do, Diana V.

PY - 2015/6/11

Y1 - 2015/6/11

N2 - The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial.

AB - The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial.

KW - AMD

KW - Age-related macular degeneration

KW - Complement inhibition

UR - http://www.scopus.com/inward/record.url?scp=84934756694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934756694&partnerID=8YFLogxK

U2 - 10.2147/OPTH.S59725

DO - 10.2147/OPTH.S59725

M3 - Review article

C2 - 26089637

AN - SCOPUS:84934756694

SN - 1177-5467

VL - 9

SP - 1049

EP - 1056

JO - Clinical Ophthalmology

JF - Clinical Ophthalmology

ER -

Potential role of lampalizumab for treatment of geographic atrophy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this