Potentiation of ethanol fatty liver in rats by chronic administration of nicotinic acid

Michael F. Sorrell; Herman Baker; Dean J. Tuma; Oscar Frank; Anthony J. Barak

doi:10.1016/0005-2760(76)90095-3

Potentiation of ethanol fatty liver in rats by chronic administration of nicotinic acid

Michael F. Sorrell, Herman Baker, Dean J. Tuma, Oscar Frank, Anthony J. Barak

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two groups of rats were fed isocalorically on alcohol and control semi-liquid diet for 28 days; two other groups had the same diets except for supplementation with nicotinic acid at 50 mg/100 ml of diet. Blood ethanol levels were unaffected by nicotinic acid administration, even though nicotinic acid was well absorbed and stored in the liver. Lipid analyses of liver and plasma after 28 days revealed that nicotinic acid, per se, stimulated fatty infiltration of the liver and this effect was potentiated when given in conjunction with ethanol.

Original language	English (US)
Pages (from-to)	231-238
Number of pages	8
Journal	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume	450
Issue number	2
DOIs	https://doi.org/10.1016/0005-2760(76)90095-3
State	Published - Nov 19 1976

ASJC Scopus subject areas

Biophysics
Biochemistry
Endocrinology

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title = "Potentiation of ethanol fatty liver in rats by chronic administration of nicotinic acid",

abstract = "Two groups of rats were fed isocalorically on alcohol and control semi-liquid diet for 28 days; two other groups had the same diets except for supplementation with nicotinic acid at 50 mg/100 ml of diet. Blood ethanol levels were unaffected by nicotinic acid administration, even though nicotinic acid was well absorbed and stored in the liver. Lipid analyses of liver and plasma after 28 days revealed that nicotinic acid, per se, stimulated fatty infiltration of the liver and this effect was potentiated when given in conjunction with ethanol.",

author = "Sorrell, {Michael F.} and Herman Baker and Tuma, {Dean J.} and Oscar Frank and Barak, {Anthony J.}",

note = "Funding Information: This work was conducted under Veterans Administration project number 0804-04. Dr. M.F. Sorrel1 was supported in part by Academic Career Development Award No. AM 70316 from the National Institute of Arthritis, Metabolism and Digestive Diseases.T his work was supported in part by a grant from the Swanson Center for Nutrition, Inc., Omaha, Nebraska, 68105, U.S.A.",

year = "1976",

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doi = "10.1016/0005-2760(76)90095-3",

language = "English (US)",

volume = "450",

pages = "231--238",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

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T1 - Potentiation of ethanol fatty liver in rats by chronic administration of nicotinic acid

AU - Sorrell, Michael F.

AU - Baker, Herman

AU - Tuma, Dean J.

AU - Frank, Oscar

AU - Barak, Anthony J.

N1 - Funding Information: This work was conducted under Veterans Administration project number 0804-04. Dr. M.F. Sorrel1 was supported in part by Academic Career Development Award No. AM 70316 from the National Institute of Arthritis, Metabolism and Digestive Diseases.T his work was supported in part by a grant from the Swanson Center for Nutrition, Inc., Omaha, Nebraska, 68105, U.S.A.

PY - 1976/11/19

Y1 - 1976/11/19

N2 - Two groups of rats were fed isocalorically on alcohol and control semi-liquid diet for 28 days; two other groups had the same diets except for supplementation with nicotinic acid at 50 mg/100 ml of diet. Blood ethanol levels were unaffected by nicotinic acid administration, even though nicotinic acid was well absorbed and stored in the liver. Lipid analyses of liver and plasma after 28 days revealed that nicotinic acid, per se, stimulated fatty infiltration of the liver and this effect was potentiated when given in conjunction with ethanol.

AB - Two groups of rats were fed isocalorically on alcohol and control semi-liquid diet for 28 days; two other groups had the same diets except for supplementation with nicotinic acid at 50 mg/100 ml of diet. Blood ethanol levels were unaffected by nicotinic acid administration, even though nicotinic acid was well absorbed and stored in the liver. Lipid analyses of liver and plasma after 28 days revealed that nicotinic acid, per se, stimulated fatty infiltration of the liver and this effect was potentiated when given in conjunction with ethanol.

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