Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li; Lisa Elmén; Igor Segota; Yibo Xian; Roberto Tinoco; Yongmei Feng; Yu Fujita; Rafael R. Segura Muñoz; Robert Schmaltz; Linda M. Bradley; Amanda Ramer-Tait; Raphy Zarecki; Tao Long; Scott N. Peterson; Ze'ev A. Ronai

doi:10.1016/j.celrep.2020.01.035

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li, Lisa Elmén, Igor Segota, Yibo Xian, Roberto Tinoco, Yongmei Feng, Yu Fujita, Rafael R. Segura Muñoz, Robert Schmaltz, Linda M. Bradley, Amanda Ramer-Tait, Raphy Zarecki, Tao Long, Scott N. Peterson, Ze'ev A. Ronai

Food Science and Technology

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.

Original language	English (US)
Pages (from-to)	1753-1766.e6
Journal	Cell Reports
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2020.01.035
State	Published - Feb 11 2020

Keywords

MEK inhibitor
anti-tumor immunity
colon cancer
gut microbiota
inulin
melanoma
mucin
prebiotics
therapy resistance

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2020.01.035

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Li, Y., Elmén, L., Segota, I., Xian, Y., Tinoco, R., Feng, Y., Fujita, Y., Segura Muñoz, R. R., Schmaltz, R., Bradley, L. M., Ramer-Tait, A., Zarecki, R., Long, T., Peterson, S. N., & Ronai, Z. A. (2020). Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth. Cell Reports, 30(6), 1753-1766.e6. https://doi.org/10.1016/j.celrep.2020.01.035

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth. / Li, Yan; Elmén, Lisa; Segota, Igor; Xian, Yibo; Tinoco, Roberto; Feng, Yongmei; Fujita, Yu; Segura Muñoz, Rafael R.; Schmaltz, Robert; Bradley, Linda M.; Ramer-Tait, Amanda; Zarecki, Raphy; Long, Tao; Peterson, Scott N.; Ronai, Ze'ev A.

In: Cell Reports, Vol. 30, No. 6, 11.02.2020, p. 1753-1766.e6.

Research output: Contribution to journal › Article

Li, Yan ; Elmén, Lisa ; Segota, Igor ; Xian, Yibo ; Tinoco, Roberto ; Feng, Yongmei ; Fujita, Yu ; Segura Muñoz, Rafael R. ; Schmaltz, Robert ; Bradley, Linda M. ; Ramer-Tait, Amanda ; Zarecki, Raphy ; Long, Tao ; Peterson, Scott N. ; Ronai, Ze'ev A. / Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth. In: Cell Reports. 2020 ; Vol. 30, No. 6. pp. 1753-1766.e6.

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abstract = "Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.",

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