Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li, Lisa Elmén, Igor Segota, Yibo Xian, Roberto Tinoco, Yongmei Feng, Yu Fujita, Rafael R. Segura Muñoz, Robert Schmaltz, Linda M. Bradley, Amanda Ramer-Tait, Raphy Zarecki, Tao Long, Scott N. Peterson, Ze'ev A. Ronai

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.

Original languageEnglish (US)
Pages (from-to)1753-1766.e6
JournalCell Reports
Issue number6
StatePublished - Feb 11 2020


  • MEK inhibitor
  • anti-tumor immunity
  • colon cancer
  • gut microbiota
  • inulin
  • melanoma
  • mucin
  • prebiotics
  • therapy resistance

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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