Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li, Lisa Elmén, Igor Segota, Yibo Xian, Roberto Tinoco, Yongmei Feng, Yu Fujita, Rafael R. Segura Muñoz, Robert Schmaltz, Linda M. Bradley, Amanda Ramer-Tait, Raphy Zarecki, Tao Long, Scott N. Peterson, Ze'ev A. Ronai

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.

Original languageEnglish (US)
Pages (from-to)1753-1766.e6
JournalCell Reports
Volume30
Issue number6
DOIs
StatePublished - Feb 11 2020

Keywords

  • MEK inhibitor
  • anti-tumor immunity
  • colon cancer
  • gut microbiota
  • inulin
  • melanoma
  • mucin
  • prebiotics
  • therapy resistance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth'. Together they form a unique fingerprint.

  • Cite this

    Li, Y., Elmén, L., Segota, I., Xian, Y., Tinoco, R., Feng, Y., Fujita, Y., Segura Muñoz, R. R., Schmaltz, R., Bradley, L. M., Ramer-Tait, A., Zarecki, R., Long, T., Peterson, S. N., & Ronai, Z. A. (2020). Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth. Cell Reports, 30(6), 1753-1766.e6. https://doi.org/10.1016/j.celrep.2020.01.035