@article{18ed047401e841a096dd00e3dec2f87a,
title = "Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth",
abstract = "Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.",
keywords = "MEK inhibitor, anti-tumor immunity, colon cancer, gut microbiota, inulin, melanoma, mucin, prebiotics, therapy resistance",
author = "Yan Li and Lisa Elm{\'e}n and Igor Segota and Yibo Xian and Roberto Tinoco and Yongmei Feng and Yu Fujita and {Segura Mu{\~n}oz}, {Rafael R.} and Robert Schmaltz and Bradley, {Linda M.} and Amanda Ramer-Tait and Raphy Zarecki and Tao Long and Peterson, {Scott N.} and Ronai, {Ze'ev A.}",
note = "Funding Information: We thank members of the Ronai lab for discussions and Miguel A. Tam (BioLegend) for the gift of the anti-PD-1 antibodies. Support through grant P30 CA030199 to the analytical genomics, vivarium, fluorescence-activated cell sorting (FACS), and histology core facilities at Sanford Burnham Prebys Medical Discovery Institute ( NCI Cancer Center) is gratefully acknowledged. Support from NCI OIA grants R35CA197465 (to Z.A.R.), R01 CA216187 (to L.M.B., S.N.P., and Z.A.R.), Melanoma Research Alliance award 509524 (Z.A.R.), and CDMRP award CA150892 (Y.L.) are gratefully acknowledged. Funding Information: We thank members of the Ronai lab for discussions and Miguel A. Tam (BioLegend) for the gift of the anti-PD-1 antibodies. Support through grant P30 CA030199 to the analytical genomics, vivarium, fluorescence-activated cell sorting (FACS), and histology core facilities at Sanford Burnham Prebys Medical Discovery Institute (NCI Cancer Center) is gratefully acknowledged. Support from NCI OIA grants R35CA197465 (to Z.A.R.), R01 CA216187 (to L.M.B. S.N.P. and Z.A.R.), Melanoma Research Alliance award 509524 (Z.A.R.), and CDMRP award CA150892 (Y.L.) are gratefully acknowledged. Y.L. L.E. I.S. Y.X. R.T. Y. Feng, Y. Fu, R.S.S.M. and R.S. performed the experiments; Y.L. L.E. I.S. Y.X. R.T. L.M.B. A.R.-T. R.Z. T.L. S.N.P. and Z.A.R. analyzed the data; Z.A.R. S.N.P. T.L. R.Z. A.R.-T. L.M.B. and Y.L. designed the experiments; Z.A.R. S.N.P. L.M.B. T.L. R.Z. and Y.L. wrote the manuscript. Z.A.R. is a co-founder and serves as a scientific advisor to Pangea Therapeutics. All other authors declare no competing interests. A patent application detailing the findings disclosed in this manuscript has been filed by SBP Discovery. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = feb,
day = "11",
doi = "10.1016/j.celrep.2020.01.035",
language = "English (US)",
volume = "30",
pages = "1753--1766.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "6",
}