Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions

Shyam S. Mohapatra, Surinder K. Batra, Srinivas Bharadwaj, Michael Bouvet, Bard Cosman, Ajay Goel, Wilma Jogunoori, Michael J. Kelley, Lopa Mishra, Bibhuti Mishra, Subhra Mohapatra, Bhaumik Patel, Joseph R. Pisegna, Jean Pierre Raufman, Shuyun Rao, Hemant Roy, Maren Scheuner, Satish Singh, Gitanjali Vidyarthi, Jon White

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Colorectal cancer (CRC) accounts for ~9% of all cancers in the Veteran population, a fact which has focused a great deal of the attention of the VA’s research and development efforts. A field-based meeting of CRC experts was convened to discuss both challenges and opportunities in precision medicine for CRC. This group, designated as the VA Colorectal Cancer Cell-genomics Consortium (VA4C), discussed advances in CRC biology, biomarkers, and imaging for early detection and prevention. There was also a discussion of precision treatment involving fluorescence-guided surgery, targeted chemotherapies and immunotherapies, and personalized cancer treatment approaches. The overarching goal was to identify modalities that might ultimately lead to personalized cancer diagnosis and treatment. This review summarizes the findings of this VA field-based meeting, in which much of the current knowledge on CRC prescreening and treatment was discussed. It was concluded that there is a need and an opportunity to identify new targets for both the prevention of CRC and the development of effective therapies for advanced disease. Also, developing methods integrating genomic testing with tumoroid-based clinical drug response might lead to more accurate diagnosis and prognostication and more effective personalized treatment of CRC.

Original languageEnglish (US)
Pages (from-to)1123-1138
Number of pages16
JournalDigestive Diseases and Sciences
Volume63
Issue number5
DOIs
StatePublished - May 1 2018

Keywords

  • Biomarkers
  • Cancer stem cells
  • Clinical drug response
  • Colorectal cancer
  • FiSS
  • Genomic testing
  • Next generation sequencing
  • Precision Oncology Program (POP)
  • Tumoroids

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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  • Cite this

    Mohapatra, S. S., Batra, S. K., Bharadwaj, S., Bouvet, M., Cosman, B., Goel, A., Jogunoori, W., Kelley, M. J., Mishra, L., Mishra, B., Mohapatra, S., Patel, B., Pisegna, J. R., Raufman, J. P., Rao, S., Roy, H., Scheuner, M., Singh, S., Vidyarthi, G., & White, J. (2018). Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions. Digestive Diseases and Sciences, 63(5), 1123-1138. https://doi.org/10.1007/s10620-018-5000-0