@article{99bdc855479748a9b127df345bc269b2,
title = "Prediagnostic proinflammatory dietary potential is associated with all-cause mortality among african-American women with high-grade serous ovarian carcinoma",
abstract = "Background: Chronic inflammation is associated with ovarian carcinogenesis; yet, the impact of inflammatory-related exposures on outcomes has been understudied. Objective: Given the poor survival of women diagnosed with ovarian cancer, especially African-Americans, we examined whether diet-Associated inflammation, a modifiable source of chronic systemic inflammation measured by the dietary inflammatory index (DII), was associated with all-cause mortality among African-American women with ovarian carcinoma. Methods: Data were available from 490 ovarian carcinoma patients enrolled in a population-based case-control study of African-American women with ovarian cancer, the African-American Cancer Epidemiology Study. Energy-Adjusted DII (E-DII) scores were calculated based on prediagnostic dietary intake of foods alone or foods and supplements, which was self-reported using the 2005 Block Food Frequency Questionnaire. Cox proportional hazards regression was used to estimate risk of mortality overall and for the most common histotype, high-grade serous carcinoma. Additionally, we assessed interaction by age at diagnosis and smoking status. Results: Women included in this study had a median age of 57 y, and the majority of women were obese (58%), had late-stage disease (Stage III or IV, 66%), and had high-grade serous carcinoma (64%). Greater E-DII scores including supplements (indicating greater inflammatory potential) were associated with an increased risk of mortality among women with high-grade serous carcinoma (HR1-unit change: 1.08; 95% CI: 1.01, 1.17). Similar associations were observed for the E-DII excluding supplements, although not statistically significant (HR1-unit change: 1.07; 95% CI: 0.97, 1.17). There was an interaction by smoking status, where the positive association with mortality was present only among ever smokers (HRQuartile 4/Quartile 1: 2.36; 95% CI: 1.21, 4.60) but not among never smokers. Conclusions: Greater inflammatory potential of prediagnostic diet may adversely impact prognosis among African-American women with high-grade serous carcinoma, and specifically among ever smokers.",
keywords = "African-American women, cancer epidemiology, diet, dietary inflammatory index, gynecologic malignancies, inflammation, ovarian cancer, race/ethnicity",
author = "Peres, {Lauren C.} and Hebert, {James R.} and Bo Qin and Guertin, {Kristin A.} and Bandera, {Elisa V.} and Nitin Shivappa and Camacho, {Tareq F.} and Deanna Chyn and Alberg, {Anthony J.} and Barnholtz-Sloan, {Jill S.} and Bondy, {Melissa L.} and Cote, {Michele L.} and Ellen Funkhouser and Moorman, {Patricia G.} and Peters, {Edward S.} and Schwartz, {Ann G.} and Terry, {Paul D.} and Schildkraut, {Joellen M.}",
note = "Funding Information: Supported by the National Cancer Institute (R01CA142081, K99CA218681, and R00CA218681 to LCP). Additional support was provided by the Metropolitan Detroit Cancer Surveillance System with funding from the National Cancer Institute, NIH, and the Department of Health and Human Services (Contract HHSN261201000028C), and the Epidemiology Research Core, supported in part by the National Cancer Institute (P30CA22453) to the Karmanos Cancer Institute, Wayne State University School of Medicine. The New Jersey State Cancer Registry, Cancer Epidemiology Services, New Jersey Department of Health, is funded by the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute under contract HHSN261201300021I, the National Program of Cancer Registries (NPCR), Centers for Disease Control and Prevention under grant 5U58DP003931-02 as well as the State of New Jersey and the Rutgers Cancer Institute of New Jersey. Author disclosures: JRH owns controlling interest in Connecting Health Innovations LLC (CHI), a company planning to license the right to his invention of the dietary inflammatory index (DII{\textregistered}) from the University of South Carolina in order to develop computer and smart phone applications for patient counseling and dietary intervention in clinical settings. NS is an employee of CHI. The subject matter of this paper will not have any direct bearing on that work, nor has that activity exerted any influence on this project. All other authors, no conflicts of interest. Supplemental Tables 1 and 2 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/. Address correspondence to LCP (e-mail: Lauren.Peres@moffitt.org). Abbreviations used: AACES, African-American Cancer Epidemiology Study; DII, dietary inflammatory index; E-DII, energy-adjusted dietary inflammatory index; LIVES, Lifestyle Intervention for Ovarian Cancer Enhanced Survival; ROS, reactive oxygen species. Publisher Copyright: Copyright {\textcopyright} American Society for Nutrition 2019.",
year = "2019",
month = sep,
day = "1",
doi = "10.1093/jn/nxz098",
language = "English (US)",
volume = "149",
pages = "1606--1616",
journal = "The Journal of nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "9",
}