Predictive value and diagnostic accuracy of F-18-fluoro-deoxy-glucose positron emission tomography treated grade 1 and 2 follicular lymphoma

Shrinivas Bishu, Joanna M. Quigley, Shreenath R. Bishu, Sarah M. Olsasky, Richard A. Stem, Valerie K. Shostrom, Karen P. Holdeman, Subash Paknikar, James O. Armitage, Jordan H. Hankins

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

F-18-fluoro-deoxy-glucose positron emission tomography (PET) is a powerful tool for the imaging of aggressive B-cell lymphomas. In contrast, there is relatively little data on PET in follicular lymphoma grade 1 (FL-1) and grade 2 (FL-2). In this manuscript, we present our findings utilizing PET in treated FL-1 and FL-2. A retrospective review of patients who underwent PET examinations at our institution produced 95 PET examinations among 31 patients with FL-1 and FL-2. PET was obtained at initial staging, mid-induction and post-treatment. Results were compared with clinical follow-up. PET had high sensitivity (95%) and specificity (88%) for lesion detection in treated FL-1 and FL-2. Abnormal foci in FL-1 and FL-2 had similar intensities. Post-induction PET positive patients had shorter mean progression free survivals compared with PET negative patients (p-value ≤0.001), post-salvage PET positive trended toward shorter mean response duration compared with negative patients (p-value: 0.09). Our results indicate that PET is accurate in the diagnostic assessment of treated FL-1 and FL-2 and, post-treatment PET positive patients are likely to relapse prior to PET negative patients.

Original languageEnglish (US)
Pages (from-to)1548-1555
Number of pages8
JournalLeukemia and Lymphoma
Volume48
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Follicular lymphoma grade 1
  • Follicular lymphoma grade 2
  • PET
  • Staging
  • Therapeutic assessment

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Predictive value and diagnostic accuracy of F-18-fluoro-deoxy-glucose positron emission tomography treated grade 1 and 2 follicular lymphoma'. Together they form a unique fingerprint.

  • Cite this

    Bishu, S., Quigley, J. M., Bishu, S. R., Olsasky, S. M., Stem, R. A., Shostrom, V. K., Holdeman, K. P., Paknikar, S., Armitage, J. O., & Hankins, J. H. (2007). Predictive value and diagnostic accuracy of F-18-fluoro-deoxy-glucose positron emission tomography treated grade 1 and 2 follicular lymphoma. Leukemia and Lymphoma, 48(8), 1548-1555. https://doi.org/10.1080/10428190701422059