Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-β receptor promoter DNA

Vinod B. Agarkar; Nigar D. Babayeva; Angie Rizzino; Tahir H. Tahirov

doi:10.1107/S1744309109038007

Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-β receptor promoter DNA

Vinod B. Agarkar, Nigar D. Babayeva, Angie Rizzino, Tahir H. Tahirov

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Ets proteins are transcription factors that activate or repress the expression of genes that are involved in various biological processes, including cellular pro - liferation, differentiation, development, transformation and apoptosis. Like other Ets-family members, Elf3 functions as a sequence-specific DNA-binding transcriptional factor. A mouse Elf3 C - terminal fragment (amino-acid residues 269-371) containing the DNA-binding domain has been crystallized in complex with mouse type II TGF-β receptor promoter (TβR-II) DNA. The crystals belonged to space group P2₁2 ₁2₁, with unit-cell parameters a = 42.66, b = 52, c = 99.78 Å, and diffracted to a resolution of 2.2 Å.

Original language	English (US)
Pages (from-to)	1261-1263
Number of pages	3
Journal	Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Volume	65
Issue number	12
DOIs	https://doi.org/10.1107/S1744309109038007
State	Published - 2009

Keywords

Cancer
Elf3
Ets
Transcription factors

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Genetics
Condensed Matter Physics

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10.1107/S1744309109038007

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Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-β receptor promoter DNA. / Agarkar, Vinod B.; Babayeva, Nigar D.; Rizzino, Angie et al.
In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications, Vol. 65, No. 12, 2009, p. 1261-1263.

Research output: Contribution to journal › Article › peer-review

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AU - Agarkar, Vinod B.

AU - Babayeva, Nigar D.

AU - Rizzino, Angie

AU - Tahirov, Tahir H.

PY - 2009

Y1 - 2009

N2 - Ets proteins are transcription factors that activate or repress the expression of genes that are involved in various biological processes, including cellular pro - liferation, differentiation, development, transformation and apoptosis. Like other Ets-family members, Elf3 functions as a sequence-specific DNA-binding transcriptional factor. A mouse Elf3 C - terminal fragment (amino-acid residues 269-371) containing the DNA-binding domain has been crystallized in complex with mouse type II TGF-β receptor promoter (TβR-II) DNA. The crystals belonged to space group P212 121, with unit-cell parameters a = 42.66, b = 52, c = 99.78 Å, and diffracted to a resolution of 2.2 Å.

AB - Ets proteins are transcription factors that activate or repress the expression of genes that are involved in various biological processes, including cellular pro - liferation, differentiation, development, transformation and apoptosis. Like other Ets-family members, Elf3 functions as a sequence-specific DNA-binding transcriptional factor. A mouse Elf3 C - terminal fragment (amino-acid residues 269-371) containing the DNA-binding domain has been crystallized in complex with mouse type II TGF-β receptor promoter (TβR-II) DNA. The crystals belonged to space group P212 121, with unit-cell parameters a = 42.66, b = 52, c = 99.78 Å, and diffracted to a resolution of 2.2 Å.

KW - Cancer

KW - Elf3

KW - Ets

KW - Transcription factors

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Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-β receptor promoter DNA

Abstract

Keywords

ASJC Scopus subject areas

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