TY - CONF
T1 - Preliminary investigation of the mechanics of a novel thoracic cavity extra pulmonary oxygenation device
AU - Aghabaglou, Fariba
AU - Legband, Nathan D.
AU - Xie, Wanchuan
AU - Kreikemeier-Bower, Craig
AU - Buesing, Keely
AU - Slagle, Connor
AU - Borden, Mark
AU - Terry, Benjamin S.
N1 - Funding Information:
We wish to thank UNL's Institutional Animal Care staff who helped us in performing the procedures and for caring for the animals used in this study. We also wish to thank our collaborators at University of Nebraska, Medical Center and University of Colorado, Boulder. This research was supported by the National Institutes of Health, DHHS-NHLBI-1-R21-HL129144-01.
Publisher Copyright:
Copyright © 2018 ASME.
PY - 2018
Y1 - 2018
N2 - Acute respiratory distress syndrome (ARDS) arising from trauma, sepsis, pneumonia or other diseases has been acknowledged to be a major clinical problem in respiratory medicine. Hypoxia and hypercapnia arising from ARDS are life-threating particularly in children and elderly people. The reported mortality rate for ARDS is high. Current methods for treating patients who have limited or no lung function are ineffective or insufficient and present additional risks to the patients. In this research, we have explored new methods of infusing phospholipid-coated oxygen microbubbles (OMBs) to the thoracic cavity in order to oxygenate patients suffering from ARDS and hypoxemia. In our previous work, OMBs have been shown to be effective in treating hypoxia in models of LPS lung injury and lung trauma in rats and rabbits. In this study, we have developed a novel thoracic cavity extrapulmonary oxygenation devices using OMBs and test this device in a benchtop test and in vivo experiment on a large animal (pig) right pneumothorax injury model.
AB - Acute respiratory distress syndrome (ARDS) arising from trauma, sepsis, pneumonia or other diseases has been acknowledged to be a major clinical problem in respiratory medicine. Hypoxia and hypercapnia arising from ARDS are life-threating particularly in children and elderly people. The reported mortality rate for ARDS is high. Current methods for treating patients who have limited or no lung function are ineffective or insufficient and present additional risks to the patients. In this research, we have explored new methods of infusing phospholipid-coated oxygen microbubbles (OMBs) to the thoracic cavity in order to oxygenate patients suffering from ARDS and hypoxemia. In our previous work, OMBs have been shown to be effective in treating hypoxia in models of LPS lung injury and lung trauma in rats and rabbits. In this study, we have developed a novel thoracic cavity extrapulmonary oxygenation devices using OMBs and test this device in a benchtop test and in vivo experiment on a large animal (pig) right pneumothorax injury model.
UR - http://www.scopus.com/inward/record.url?scp=85049628268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049628268&partnerID=8YFLogxK
U2 - 10.1115/DMD2018-6908
DO - 10.1115/DMD2018-6908
M3 - Paper
AN - SCOPUS:85049628268
T2 - 2018 Design of Medical Devices Conference, DMD 2018
Y2 - 9 April 2018 through 12 April 2018
ER -