Premixed Antibiotic Bone Cement. An In Vitro Comparison of Antimicrobial Efficacy

Matthew W. Squire, Brian J. Ludwig, Jonathan R. Thompson, Jason Jagodzinski, Derek Hall, David Andes

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


After Food and Drug Administration (FDA) approval of premixed antibiotic bone cements (polymethylmethacrylate [PMMA]), these products are being used with increasing frequency during revision and primary hip and knee arthroplasties. To date, no studies have compared the antimicrobial efficacy of more than 2 products directly. Using a 7-day modified Kirby-Bauer assay, we assessed the in vitro antibacterial properties of 5 FDA-approved, commercially available antibiotic PMMAs. Significant differences in antimicrobial activity were noted among the antibiotic PMMA products included in this investigation. Antibacterial activity of all products tested was greatest on day 1 and rapidly diminished thereafter. Results of this investigation suggest that the antibacterial efficacies of premixed antibiotic PMMA products are not equivalent.

Original languageEnglish (US)
Pages (from-to)110-114
Number of pages5
JournalJournal of Arthroplasty
Issue number6 SUPPL.
StatePublished - Sep 2008
Externally publishedYes


  • polymethylmethacrylate
  • premixed antibiotic bone cement
  • total hip anthroplasty
  • total knee arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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