Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats

Yiu K. Fung; J. A. Reed; Yuen Sum Lau

doi:10.1016/0306-3623(89)90108-0

Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats

Yiu K. Fung, J. A. Reed, Yuen Sum Lau

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35 Scopus citations

Abstract

1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.

Original language	English (US)
Pages (from-to)	689-693
Number of pages	5
Journal	General Pharmacology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/0306-3623(89)90108-0
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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abstract = "1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.",

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N2 - 1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.

AB - 1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.

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Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats

Abstract

ASJC Scopus subject areas

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