Prenatal exposure to phenobarbital and quantifiable alterations in the electroencephalogram of adult rat offspring

Glenn T. Livezey, William F. Rayburn, Carl V. Smith

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

OBJECTIVE: Our purpose was to measure central nervous system insult from prenatal phenobarbital by quantified electroencephalographic evaluation of mature rat offspring. STUDY DESIGN: Twenty-four adult female rats were given phenobarbital as 0, 20, 40, or 60 mg/kg/day subcutaneously between 9 and 10 Ann for 28 days before breeding and throughout gestation. The electroencephalograms of 90-day-old offspring were sampled over 24 hours and converted to the power spectra. RESULTS: Female offspring exposed prenatally to 20 mg and males exposed prenatally to 40 mg displayed an increase in delta and a decrease in alpha and middle-beta waveform activities. Females exposed prenatally to 40 mg and males exposed prenatally to 60 mg displayed decreases in delta, theta, alpha, and middle-beta activities. CONCLUSIONS: Prenatal phenobarbital exposure produced dose- and sex-dependent changes in the electroencephalogram of mature offspring consistent with a generalized deficit in the neuronal synchronization mechanisms that are critical for normal sleep and learning.

Original languageEnglish (US)
Pages (from-to)1611-1615
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume167
Issue number6
DOIs
StatePublished - Dec 1992

Keywords

  • Prenatal
  • electroencephalogram
  • phenobarbital
  • power spectra
  • rat

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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