Prenatal Prediction of Risk of the Fetal Hydantoin Syndrome

To the Editor: After the publication of our paper “Prenatal Prediction of Risk of the Fetal Hydantoin Syndrome” (May 31, 1990, issue),¹ our laboratory received many requests to assay epoxide hydrolase activity in samples of chorionic villi. Our prior work had established standards for measuring this enzyme in amniocytes and skin fibroblasts and used those standards to assist in predicting the risk of the fetal hydantoin syndrome. In an effort to determine whether measurement of epoxide activity in chorionic-villus samples could be used in a similar manner, we cultured 50 samples randomly obtained from pregnant women who were requesting fetal…