Preparation of D-cycloserine and 13C-labeled D-cycloserine

Nathan C. Thacker, Judit Molnár-Tóth, Judy L. Miska, Raul G. Barletta, James M. Takacs

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


D-Cycloserine (DCS), a second stage drug for the treatment of tuberculosis, is synthesized in 19.8% overall yield from DL-serine methyl ester. This synthetic route gives both enantiomers of cycloserine via a corrected and improved one pot resolution procedure using D- and L-tartaric acids. The route is used to synthesize a 13C-labeled derivative for use in biological studies.

Original languageEnglish (US)
Pages (from-to)1575-1582
Number of pages8
Issue number2
StatePublished - 2012

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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