Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients with Chronic Pancreatitis

Namita Gupta, Shailender Singh, Luciano Vargas, Timothy E. Moore, Valerie K. Shostrom, Brian P. Boerner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objectives Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States. Methods This was a prospective, observational study. Subjects with CP underwent dual-energy x-ray absorptiometry scan. Blood was assayed for vitamin D, sex hormones, and a metabolic panel. History was obtained for fractures, menopause, hypogonadal symptoms, and opioid medication doses. Low BMD was defined by both World Health Organization and the International Society for Clinical Densitometry criteria. Results Depending on criteria used, 37% to 55% of our cohort had low BMD. Subjects with low and normal BMD had similar vitamin D levels. Hypogonadism was present in 27% of nonmenopausal subjects and was associated with reduced lumbar spine BMD in subjects 30 years or older. Conclusions Patients with CP are at increased risk of low BMD which is likely multifactorial. Hypogonadism, possibly related to opioid pain medications, may be an independent risk factor for low BMD in CP.

Original languageEnglish (US)
Pages (from-to)387-395
Number of pages9
Issue number3
StatePublished - Mar 1 2019


  • chronic pancreatitis
  • hypogonadism
  • low bone mineral density
  • opioid
  • osteoporosis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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