TY - JOUR
T1 - Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients with Chronic Pancreatitis
AU - Gupta, Namita
AU - Singh, Shailender
AU - Vargas, Luciano
AU - Moore, Timothy E.
AU - Shostrom, Valerie K.
AU - Boerner, Brian P.
N1 - Funding Information:
From the Divisions of *Endocrinology and †Gastroenterology, Department of Internal Medicine, ‡Division of Transplant Surgery, Department of Surgery, §Department of Radiology, and ||College of Public Health, University of Nebraska Medical Center, Omaha, NE. Received for publication July 17, 2018; accepted January 6, 2019. Address correspondence to: Brian P. Boerner, MD, Department of Internal Medicine, University of Nebraska Medical Center, 984130 Nebraska Medical Center, Omaha, NE 68198 (e‐mail: [email protected]). This work was supported by generous funding from the Center for Clinical and Translational Research, University of Nebraska Medical Center, Omaha, NE. B.P.B. received educational grants from AstraZenca and Sanofi related to continuing medical education presentations. All other authors declare no conflict of interest or funding. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001257
Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Objectives Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States. Methods This was a prospective, observational study. Subjects with CP underwent dual-energy x-ray absorptiometry scan. Blood was assayed for vitamin D, sex hormones, and a metabolic panel. History was obtained for fractures, menopause, hypogonadal symptoms, and opioid medication doses. Low BMD was defined by both World Health Organization and the International Society for Clinical Densitometry criteria. Results Depending on criteria used, 37% to 55% of our cohort had low BMD. Subjects with low and normal BMD had similar vitamin D levels. Hypogonadism was present in 27% of nonmenopausal subjects and was associated with reduced lumbar spine BMD in subjects 30 years or older. Conclusions Patients with CP are at increased risk of low BMD which is likely multifactorial. Hypogonadism, possibly related to opioid pain medications, may be an independent risk factor for low BMD in CP.
AB - Objectives Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States. Methods This was a prospective, observational study. Subjects with CP underwent dual-energy x-ray absorptiometry scan. Blood was assayed for vitamin D, sex hormones, and a metabolic panel. History was obtained for fractures, menopause, hypogonadal symptoms, and opioid medication doses. Low BMD was defined by both World Health Organization and the International Society for Clinical Densitometry criteria. Results Depending on criteria used, 37% to 55% of our cohort had low BMD. Subjects with low and normal BMD had similar vitamin D levels. Hypogonadism was present in 27% of nonmenopausal subjects and was associated with reduced lumbar spine BMD in subjects 30 years or older. Conclusions Patients with CP are at increased risk of low BMD which is likely multifactorial. Hypogonadism, possibly related to opioid pain medications, may be an independent risk factor for low BMD in CP.
KW - chronic pancreatitis
KW - hypogonadism
KW - low bone mineral density
KW - opioid
KW - osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=85062692961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062692961&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000001257
DO - 10.1097/MPA.0000000000001257
M3 - Article
C2 - 30768576
AN - SCOPUS:85062692961
SN - 0885-3177
VL - 48
SP - 387
EP - 395
JO - Pancreas
JF - Pancreas
IS - 3
ER -