TY - JOUR
T1 - Primary Carcinoid Tumor of the Renal Pelvis Arising from Intestinal Metaplasia
T2 - An Unusual Histogenetic Pathway?
AU - Kuba, Maria G.
AU - Wasserman, Allison
AU - Vnencak-Jones, Cindy L.
AU - Bridge, Julia A.
AU - Gellert, Lan
AU - Hameed, Omar
AU - Giannico, Giovanna A.
PY - 2017
Y1 - 2017
N2 - Objectives: Primary carcinoid tumor of the renal pelvis is a rare neoplasm with few cases reported in the literature. Here we present the clinical and histopathologic findings of a primary carcinoid tumor arising in the left renal pelvis of a horseshoe kidney in a 61-year-old female patient. Materials and Methods: Pathologic features were evaluated with standard hematoxylin and eosin sections and immunohistochemical studies. A literature review was performed to place our case in context to previous reports. Results: The tumor was associated with intestinal metaplasia with high-grade dysplasia and neuroendocrine hyperplasia. Molecular testing for microsatellite instability and loss of heterozygosity were negative. Conclusions: This report portrays a unique presentation of carcinoid tumor arising from intestinal metaplasia of the pelvic urothelium, and supports its histogenesis from urothelial intestinal metaplasia and neuroendocrine hyperplasia.
AB - Objectives: Primary carcinoid tumor of the renal pelvis is a rare neoplasm with few cases reported in the literature. Here we present the clinical and histopathologic findings of a primary carcinoid tumor arising in the left renal pelvis of a horseshoe kidney in a 61-year-old female patient. Materials and Methods: Pathologic features were evaluated with standard hematoxylin and eosin sections and immunohistochemical studies. A literature review was performed to place our case in context to previous reports. Results: The tumor was associated with intestinal metaplasia with high-grade dysplasia and neuroendocrine hyperplasia. Molecular testing for microsatellite instability and loss of heterozygosity were negative. Conclusions: This report portrays a unique presentation of carcinoid tumor arising from intestinal metaplasia of the pelvic urothelium, and supports its histogenesis from urothelial intestinal metaplasia and neuroendocrine hyperplasia.
KW - intestinal metaplasia
KW - kidney
KW - neuroendocrine tumor
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U2 - 10.1097/PAI.0000000000000445
DO - 10.1097/PAI.0000000000000445
M3 - Article
C2 - 27753663
AN - SCOPUS:84991515468
VL - 25
SP - e49-e57
JO - Applied Immunohistochemistry
JF - Applied Immunohistochemistry
SN - 1541-2016
IS - 7
ER -