Primary Carcinoid Tumor of the Renal Pelvis Arising from Intestinal Metaplasia: An Unusual Histogenetic Pathway?

Maria G. Kuba, Allison Wasserman, Cindy L. Vnencak-Jones, Julia A. Bridge, Lan Gellert, Omar Hameed, Giovanna A. Giannico

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objectives: Primary carcinoid tumor of the renal pelvis is a rare neoplasm with few cases reported in the literature. Here we present the clinical and histopathologic findings of a primary carcinoid tumor arising in the left renal pelvis of a horseshoe kidney in a 61-year-old female patient. Materials and Methods: Pathologic features were evaluated with standard hematoxylin and eosin sections and immunohistochemical studies. A literature review was performed to place our case in context to previous reports. Results: The tumor was associated with intestinal metaplasia with high-grade dysplasia and neuroendocrine hyperplasia. Molecular testing for microsatellite instability and loss of heterozygosity were negative. Conclusions: This report portrays a unique presentation of carcinoid tumor arising from intestinal metaplasia of the pelvic urothelium, and supports its histogenesis from urothelial intestinal metaplasia and neuroendocrine hyperplasia.

Original languageEnglish (US)
Pages (from-to)e49-e57
JournalApplied Immunohistochemistry and Molecular Morphology
Volume25
Issue number7
DOIs
StatePublished - 2017

Keywords

  • intestinal metaplasia
  • kidney
  • neuroendocrine tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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