Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II)

Daniel M. Hays, R. Beverly Raney, Walter Lawrence, Melvin Tefft, Edward H. Soule, William M. Crist, Mary Foulkes, Harold M. Maurer, Rhabdomyosarcoma Study Committee Intergroup

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45 Scopus citations


Twenty-nine children (24, male: 5, female) with non-disseminated rhabomyosarcomas of the bladder or prostate were treated (1978-1980) by a primary chemotherapy regimen consisting of vincristine, actinomycin D, and cyclosphamide ("pulse" VAC), with or without local radiotherapy. During the initial 20 wk of chemotherapy, nine children achieved a Clinical Complete Response (CCR). Three of these are without evidence of disease (NED) and have functional bladders, two following partial cystectomy. Four who achieved a CCR subsequently relapsed or remained biopsy positive, but are at present NED following radiotherapy and anterior exenteration. Two patients who achieved CCR status relapsed and have died of disease. Twelve patients had a Clinical Partial Response (CPR) in <20 wk and two others in <40 wk. Seven of these are NED with intact bladders following chemotherapy-radiotherapy; and an additional patient is NED following partial cystectomy. Four patients in the CPR group have been treated by exenteration following failure to achieve complete response, and are NED. One patient had died, and one has progressive disease. Six patients had an inadequate response to chemotherapy (NR). Anterior exenteration was carried out in three, and two of these have survived. The overall results in these 29 patients are: (A) alive and disease-free with functional bladders, 11; (B) alive and disease-free following anterior exenteration, 10; and (C) dead or death from tumor anticipated, 8. The function of retained bladders (11) has been satisfactory.

Original languageEnglish (US)
Pages (from-to)812-820
Number of pages9
JournalJournal of pediatric surgery
Issue number6
StatePublished - Dec 1982
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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