Primary extramedullary plasmacytoma in the atria of the heart

Xiaoying Wan, Stefano Tarantolo, Donald F. Orton, Timothy C. Greiner

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A rare case of primary extramedullary plasmacytoma of the heart is described. The large space-occupying tumor in the atrial wall and its associated significant pericardial effusion caused marked impairment of cardiovascular function. The diagnosis was made via intravenous biopsy. Immunohistochemistry demonstrated CD45 and kappa light chain expression. Other B-cell- and T-cell-specific lymphoid markers were negative. Elevated kappa light chain was detected in serum by immunofixation electrophoresis. The differential diagnosis of plasmacytoma should be considered in cardiac tumors when routine screening is negative with lymphoid (CD20, CD3) and soft tissue immunohistochemical markers.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalCardiovascular Pathology
Issue number3
StatePublished - 2001


  • Heart
  • Immunohistochemistry
  • Plasmacytoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine

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