Primary lateral sclerosis (PLS) functional rating scale: PLS-specific clinimetric scale

the PLSFRS study group

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Introduction: Our research aim was to develop a novel clinimetric scale sensitive enough to detect disease progression in primary lateral sclerosis (PLS). Methods: A prototype of the PLS Functional Rating Scale (PLSFRS) was generated. Seventy-seven participants with PLS were enrolled and evaluated at 21 sites that comprised the PLSFRS study group. Participants were assessed using the PLSFRS, Neuro-Quality of Life (QoL), Schwab-England Activities of Daily Living (ADL), and the Clinical Global Impression of Change scales. Participants completed telephone assessments at 12, 24, and 48 weeks after enrollment. Results: The PLSFRS demonstrated internal consistency as well as intrarater, interrater, telephone test-retest reliability, and construct validity. Significant changes in disease progression were detected at 6 and 12 months; changes measured by the PLSFRS vs the ALSFRS-R were significantly higher. Discussion: The PLSFRS is a valid tool to assess the natural history of PLS in a shorter study period.

Original languageEnglish (US)
Pages (from-to)163-172
Number of pages10
JournalMuscle and Nerve
Issue number2
StatePublished - Feb 1 2020


  • MND
  • PLS
  • clinical trials
  • clinimetric scale

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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