Primary Sclerosing Cholangitis: The Emerging Role for Liver Transplantation

Alan N. Langnas, G. L. Grazi, Robert J. Stratta, R. Patrick Wood, Wagner Marujo, Rodney S. Markin, Jeremiah Donovan, David Burnett, Rowen Zetterman, Michael Sorrell, B. W. Shaw

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Primary sclerosing cholangitis is a progressive liver disease for which orthotopic liver transplantation is the only curative procedure. Questions exist regarding the role of temporizing procedures and the timing of transplantation. During the past 4 yr, we have performed liver transplants in 177 adult recipients. Twenty‐six patients (14.6%) with primary sclerosing cholangitis received 30 transplants including 12 men and 14 women. The recipients were examined for a number of preoperative and postoperative variables. The 4‐yr actuarial survival in patients with primary sclerosing cholangitis after transplantation was 88%. Patients were segregated according to preoperative risk variables. Twenty patients were low and medium risk, with one death (95% survival). Three patients were high risk, with two deaths (33% survival). In conclusion, orthotopic liver transplantation is safe and effective therapy for primary sclerosing cholangitis. Early referral for transplantation is recommended to reduce the mortality associated with this procedure in those with advanced hepatic failure.

Original languageEnglish (US)
Pages (from-to)1136-1141
Number of pages6
JournalThe American journal of gastroenterology
Volume85
Issue number9
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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