Primary skeletal Ewing's sarcoma in down syndrome

Julia A. Bridge, James R. Neff, Deborah A. Borek, Donald A. Hackbarth

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Primary skeletal Ewing's sarcoma that occured in two teenage patients with Down syndrome are reported. Cytogenetic analysis of one of these tumors showed the 11:22 translocation characteristic of Ewing's sarcoma as well as other complex karyotypic changes. The possible role of constitutional trisomy 21 in development of these sarcomas is discussed.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalCancer genetics and cytogenetics
Issue number1
StatePublished - Jul 1 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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