Priming the Proteasome to Protect against Proteotoxicity

Xuejun Wang; Hongmin Wang

doi:10.1016/j.molmed.2020.02.007

Priming the Proteasome to Protect against Proteotoxicity

Xuejun Wang, Hongmin Wang

Great Plains IDeA-CTR

Research output: Contribution to journal › Review article

Abstract

Increased proteotoxic stress (IPTS) resulting from the increased production or decreased removal of abnormally folded proteins is recognized as an important pathogenic factor for a large group of highly disabling and life-threatening human diseases, such as neurodegenerative disorders and many heart diseases. The proteasome is pivotal to the timely removal of abnormal proteins but its functional capacity often becomes inadequate in the disease conditions; consequently, proteasome functional insufficiency in return exacerbates IPTS. Recent research in proteasome biology reveals that the proteasome can be activated by endogenous protein kinases, making it possible to pharmacologically prime the proteasome for treating diseases with IPTS.

Original language	English (US)
Pages (from-to)	639-648
Number of pages	10
Journal	Trends in Molecular Medicine
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.molmed.2020.02.007
State	Published - Jul 2020

Keywords

cAMP-dependent protein kinase
cGMP-dependent protein kinase
desmin-related cardiomyopathy
phosphodiesterases
proteasome
proteotoxicity

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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Wang, X., & Wang, H. (2020). Priming the Proteasome to Protect against Proteotoxicity. Trends in Molecular Medicine, 26(7), 639-648. https://doi.org/10.1016/j.molmed.2020.02.007

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abstract = "Increased proteotoxic stress (IPTS) resulting from the increased production or decreased removal of abnormally folded proteins is recognized as an important pathogenic factor for a large group of highly disabling and life-threatening human diseases, such as neurodegenerative disorders and many heart diseases. The proteasome is pivotal to the timely removal of abnormal proteins but its functional capacity often becomes inadequate in the disease conditions; consequently, proteasome functional insufficiency in return exacerbates IPTS. Recent research in proteasome biology reveals that the proteasome can be activated by endogenous protein kinases, making it possible to pharmacologically prime the proteasome for treating diseases with IPTS.",

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