Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5

Luwen Zhang, P. Maruthi Mohan, R. Padmanabhan

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

Original languageEnglish (US)
Pages (from-to)7549-7554
Number of pages6
JournalJournal of virology
Volume66
Issue number12
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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