Progesterone:estradiol ratios at implantation in ongoing pregnancies, abortions, and nonconception cycles resulting from ovulation induction

V. M. Maclin, E. Radwanska, Z. Binor, W. P. Dmowski

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The purpose of this study was to compare progesterone (P):estradiol (E2) ratios after ovulation induction at the time of implantation in cycles resulting in ongoing pregnancies or abortions and in nonconception cycles. Material included 43 stimulated conception cycles, 29 with human menopausal gonadotropins (hMG) and human chorionic gonadotropins (hCG), 14 with clomiphene citrate (CC) with or without hCG, and 28 nonconception cycles (13 hMG and hCG, 15 CC with or without hCG). Midluteal P and E2 were measured and expressed in ng/mL. There were no differences in P:E2 ratios (mean ± SE) for ongoing pregnancies after hMG and hCG (n = 20, 112.6 ± 14.9), CC and hCG (n = 6, 97.0 ± 15.9), or CC alone (n = 5, 96.2 ± 25.5), and the data were pooled . Progesterone:estradiol ratios in 31 ongoing pregnancies and 28 nonception cycles were 107.0 ± 10.7 and 115.2 ± 12.5, respectively, both significantly higher than in 12 abortions (64.5 ± 13.2). In conclusion: (1) P:E2 ratios at the time of implantation were similar after CC with or without hCG and HMG and hCG treatment; (2) high luteal P:E2 ratio was associated with ongoing pregnancies; and (3) lower P:E2 ratio was seen in cycles leading to spontaneous abortions.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalFertility and Sterility
Volume54
Issue number2
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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