Prognostic factors in 951 nonmetastatic rhabdomyosarcoma in children: A report from the international rhabdomyosarcoma workshop

Chantal Rodary, Edmund A. Gehan, Françoise Flamant, JÖRn Treuner, Modesto Carli, Ariane Auquier, Harold Maurer

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

A total of 951 newly diagnosed patients with nonmetastatic rhabdomyosarcoma (RMS) under 21 years of age from four different cooperative study groups were analyzed to identify the most important pretreatment tumor characteristics in predicting survival. The patient characteristics considered were tumor invasiveness (T), tumor size, status of locoregional lymph nodes, and primary site. The cooperative groups and studies analyzed were: SIOP [RMS‐75 (1975–1984)], the intergroup Rhabdomyosarcoma Study [IRS‐II (1978–1982)], Federal Republic of Germany [CWS‐81 (1981–1986)] and Italy [RMS‐79 (1979–1986)], each study involving a different therapeutic protocol. Patient characteristics identified as having a significant relationship to survival by univariate analysis were (favorable features given in brackets): tumor invasiveness [T1], tumor size [ ⩽ 5 cm], status of locoregional lymph nodes [clinically negative], and primary site [orbit and genitourinary nonbladder prostate (GU‐non‐BP) sites]. T2 tumors tended to have large size (>5 cm), to be associated with positive nodes, and to have a different distribution by primary site than T1, tumors. A multivariate Cox regression analysis of the pooled data identified tumor invasiveness (T), primary site, and the interaction between T and primary site as significant predictive factors for survival. The prognosis of orbital tumors was consistently favorable regardless of T status, whereas the prognosis for “other sites” was consistently unfavorable. International cooperation in this study has permitted the identification of good and poor risk patient subgroups, permitting the focusing of therapeutic protocols to particular risk groups and setting the stage for common future therapeutic protocols for rare subgroups of patients.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalMedical and Pediatric Oncology
Volume19
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Cox regression
  • RMS
  • predictors for survival time

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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