Prognostic factors influencing survival in patients with B-cell small lymphocytic lymphoma

Marin Nola, Steven Z. Pavletic, Dennis D. Weisenburger, Lynette M. Smith, Martin A. Bast, Julie M. Vose, James O. Armitage

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The term "B-cell small lymphocytic lymphoma" (B-SLL) is generally reserved for patients with lymph node masses that show the histology and immunophenotype of B-cell chronic lymphocytic leukemia (B-CLL) but who are not leukemic. The aim of our study was to define clinical factors that predict for survival in B-SLL. Thirty-nine patients with B-SLL and with less than 5,000 mature-appearing lymphocytes/gL in the peripheral blood were studied. The median follow-up of survivors was 6.6 years (range, 1.6-12.3 years). The estimated 5-year overall survival (OS) and failure-free survival (FFS) were 66% and 23%, respectively. In the univariate analysis, significant adverse predictors for OS were age ≥60 years, B symptoms, elevated serum LDH, low hemoglobin (<11 g/dL), and high International Prognostic Index (IPI) score (3-5). In multivariate analysis, the IPI score was the only significant predictor of OS. Anemia and B symptoms were additionally predictive of poor OS in patients with low IPI scores.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalAmerican Journal of Hematology
Volume77
Issue number1
DOIs
StatePublished - Sep 2004

Keywords

  • B-CLL
  • B-SLL
  • B-cell chronic lymphocytic leukemia
  • B-cell small lymphocytic lymphoma
  • Prognosis
  • Small lymphocytic lymphoma prognosis

ASJC Scopus subject areas

  • Hematology

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