Prognostic implications of chromosome 17p deletions in human medulloblastomas

Surinder K. Batra, Roger E. McLendon, Ja Seok Koo, Shobha Castelino-Prabhu, Herbert E. Fuchs, Jeffrey P. Krischer, Henry S. Friedman, Darell D. Bigner, Sandra H. Bigner

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

DNA derived from medulloblastoma biopsies was analyzed to determine if deletions of the 17p region, mutations of the TP53 gene, or amplification of the c-myc, N-myc, EGFR (epidermal growth factor receptor), or MDM2 (murine double-minute-2) genes was indicative of a poor prognosis. Loss of heterozygosity for 17p, observed in 8/28 (29%) paired samples, was associated with a shortened survival period (p=0.045 by the logrank test). TP53 mutations occurred in 2/46 (4.3%) tumor samples. c-myc Amplification was seen in 3/43 (6.9%) cases, while none of the tumors contained amplified N-myc, EGFR, or MDM2 genes. These results demonstrate that, while only rare medulloblastomas contain TP53 gene mutations or amplification of the c-myc gene, loss of heterozygosity on chromosome 17p is indicative of a significantly worse prognosis among patients with these tumors. Further, these results provide a strong impetus for a prospective analysis of loss of heterozygosity in a cooperative group setting, which would include tumor staging, a selection of treatment modalities, and multivariate analyses.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalJournal of Neuro-Oncology
Volume24
Issue number1
DOIs
StatePublished - Feb 1995

Keywords

  • TP53
  • loss of heterozygosity
  • medulloblastomas
  • microsatellite
  • minisatellite
  • oncogenes
  • prognostic significance

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Fingerprint Dive into the research topics of 'Prognostic implications of chromosome 17p deletions in human medulloblastomas'. Together they form a unique fingerprint.

  • Cite this

    Batra, S. K., McLendon, R. E., Koo, J. S., Castelino-Prabhu, S., Fuchs, H. E., Krischer, J. P., Friedman, H. S., Bigner, D. D., & Bigner, S. H. (1995). Prognostic implications of chromosome 17p deletions in human medulloblastomas. Journal of Neuro-Oncology, 24(1), 39-45. https://doi.org/10.1007/BF01052657