Progress in the use of microarray technology to study the neurobiology of disease

Károly Mirnics, Jonathan Pevsner

Research output: Contribution to journalReview article

132 Scopus citations

Abstract

The diverse functions of the brain are mediated by neurons and glia whose phenotype is defined by a dynamically maintained set of gene transcripts, or 'transcriptome'. Large-scale analysis of gene expression in postmortem brain using microarray technology has the potential to elucidate molecular changes that occur in disease states. There are unique challenges associated with studies of postmortem brain, including limited sample sizes and variable clinical phenotypes that are typical of complex disorders. Nevertheless, recent microarray-based studies have implicated both individual dysregulated genes and abnormal patterns of gene expression in brain disorders.

Original languageEnglish (US)
Pages (from-to)434-439
Number of pages6
JournalNature Neuroscience
Volume7
Issue number5
DOIs
StatePublished - May 1 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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