Progression of type 2 to type 1 retinopathy of prematurity in the early treatment for retinopathy of prematurity study

Stephen P. Christiansen, Velma Dobson, Graham E. Quinn, William V. Good, Betty Tung, Robert J. Hardy, John D. Baker, Robert O. Hoffman, James D. Reynolds, Paul J. Rychwalski, Michael J. Shapiro

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Objective: To examine the frequency and timing of progression from type 2 to type 1 retinopathy of prematurity (ROP) in the Early Treatment for Retinopathy of Prematurity Study. Methods: Infants with prethreshold ROP that was no worse than low risk in 1 or both eyes, based on the RMROP2 model, were examined every 2 to 4 days for at least 2 weeks. Using the Early Treatment for Retinopathy of Prematurity Study-defined classification of eyes as having type 1 or type 2 prethreshold ROP, we analyzed the time to conversion from type 2 to type 1. Data were analyzed for 1 randomly selected eye for each child. Results: Of 294 eyes at first diagnosis of type 2 ROP, 65 (22.1%) progressed to type 1 (mean [SD] interval, 9.0 [6.6] days; median, 7.0 days). Of 217 eyes with type 2 ROP that had an examination in less than 7 days, 25 (11.5%) were diagnosed with type 1 ROP in less than 7 days. Of 200 eyes that continued to have type 2 disease at the first follow-up examination and underwent a subsequent examination, 24 (15.7% of the 153 eyes that had an examination in <7 days) developed type 1 ROP in less than 7 days. The risk of progression from type 2 to type 1 in less than 7 days was greatest between 33 and 36 weeks' postmenstrual age, regardless of zone of retinopathy. Conclusions: Type 1 ROP can be identified with weekly examinations in most eyes with initial diagnosis of type 2 ROP; a small subset progresses to type 1 in less than 7 days. Trial Registration: clinicaltrials.gov Identifier: NCT00027222.

Original languageEnglish (US)
Pages (from-to)461-465
Number of pages5
JournalArchives of Ophthalmology
Volume128
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint

Dive into the research topics of 'Progression of type 2 to type 1 retinopathy of prematurity in the early treatment for retinopathy of prematurity study'. Together they form a unique fingerprint.

Cite this