Progressive multifocal leukoencephalopathy in a HIV-negative patient with small lymphocytic leukemia following treatment with rituximab

Subhankar Chakraborty, Stefano R. Tarantolo, John Treves, David Sambol, Ralph J. Hauke, Surinder K. Batra

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We describe a case of progressive multifocal leukoencephalopathy (PML) caused by infection with the human polyomavirus JC virus in a patient with B-cell small lymphocytic leukemia who was treated with rituximab. The first symptoms of PML appeared immediately following the last of five cycles of rituximab, cyclophosphamide and pentostatin. Magnetic resonance imaging revealed changes consistent with PML, although JC virus DNA was not detected by polymerase chain reaction assay of the cerebrospinal fluid. A stereotactic biopsy of the brain showed histological changes consistent with PML, while electron microscopy revealed JC virus particles attached to the nuclei of astrocytes. The patient was treated supportively but died 53 days after the initial onset of symptoms.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalCase Reports in Oncology
Volume4
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • JC virus
  • Progressive multifocal leukoencephalopathy
  • Rituximab
  • Small lymphocytic leukemia

ASJC Scopus subject areas

  • Oncology

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