Proliferation and differentiation of transplanted bone marrow from mice treated with nitrogen mustard

J. G. Sharp, D. B. Thomas, C. V. Briscoe

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The majority of cells in bone marrow regenerating after the injection of nitrogen mustard are granulocytes at various stages of maturation. In an attempt to determine the processes underlying this observation, the proliferative capacity and differentiation potential of bone marrow cells derived from mice treated 8 days previously with nitrogen mustard were assayed in the irradiated mouse. Spleen colony number, the weight of the spleen and the cellularity and composition of the femoral bone marrow of the recipients, together with the radio iron content of these tissues, were measured as indices of the proliferative capacity and differentiation potential of the injected bone marrow cells. Although the vast majority of the transplanted bone marrow cells were granulocytes at various stages of maturation, the proliferative capacity and differentiation potential of the stem cell compartment of this bone marrow did not appear to have been impaired or altered.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalExperimental Hematology
Volume2
Issue number1
StatePublished - 1974

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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