Proof-of-Concept Prototype for Noninvasive Intracranial Pressure Monitoring Using Ocular Hemodynamics Under Applied Force

Tyler Ketchem, Max Twedt, Darrin Lim, Greg Bashford, Jeff A. Hawks

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Studies have suggested that elevated cerebrospinal fluid (CSF) pressure can have a damaging effect on the optic nerve and visual acuity. There is need for a noninvasive CSF pressure measurement technique. A portable device for noninvasive intracranial pressure (ICP) monitoring would have a significant impact on clinical care. A proof-of-concept prototype is used to test the feasibility of a technique for monitoring ICP changes. The proposed methodology utilizes transcranial Doppler ultrasonography to monitor blood flow through the ophthalmic and central retinal arteries while forces are applied to the cornea by a controlled actuator. Control algorithms for the device were developed and tested using an integrated experimental platform. Preliminary results using tissue-mimicking materials show the ability to differentiate between materials of differing stiffness that simulates different levels of ICP. These experiments are an initial step toward a handheld noninvasive ICP monitoring device.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalJournal of Medical Devices, Transactions of the ASME
Volume9
Issue number2
DOIs
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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