Properties and potential medical applications of regenerated casein fibers crosslinked with citric acid

Yiqi Yang, Narendra Reddy

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Regenerated protein fibers developed from casein using alkaline solutions and crosslinked with citric acid have good tensile properties and water stability but were cytotoxic. Casein is obtained as a byproduct during skim milk production but has limited industrial applications. In this research, casein was dissolved using alkaline solutions and the effects of fiber formation conditions on the tensile properties was studied before and after crosslinking with citric acid. Crosslinked casein fibers had tensile strength as high as 110. MPa and breaking elongation of 13.6%. The fibers were also stable in 90 °C water between pH 3 and 9 but were hydrolyzed at pH 11. Casein was cytotoxic and did not support the attachment and growth of mouse fibroblasts.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalInternational Journal of Biological Macromolecules
Volume51
Issue number1-2
DOIs
StatePublished - Jul 2012

Keywords

  • Biocompatibility
  • Casein
  • Crosslinking
  • Protein fibers

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

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