Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release

Jianhui Liu, Yuju Li, Xiaohuan Xia, Xiaoyu Yang, Runze Zhao, Justin Peer, Hongyun Wang, Zenghan Tong, Fengtong Gao, Hai Lin, Beiqing Wu, Yunlong Huang, Jialin C. Zheng

Research output: Contribution to journalArticle

Abstract

Propofol is an established anesthetic widely used for induction and maintenance of anesthesia. We investigated propofol for its anti-inflammatory effects on microglia and found that propofol treatment is associated with substantial lower levels of extracellular vesicles (EVs) in immune activated microglia. Importantly, EVs collected from immune activated microglia reversed propofol-mediated anti-inflammatory and neuroprotective effects, suggesting that propofol reduces proinflammatory microglia activation and microglia-mediated neurotoxicity through inhibition of EV release. These data shed new insight into a novel molecular mechanism of propofol-mediated neuroprotective and immunomodulatory effects through inhibition of EV release.

Original languageFrench
Article number476962
JournalJournal of Neuroimmunology
Volume333
DOIs
StatePublished - Aug 15 2019

Keywords

  • Anesthetics
  • Extracellular vesicles
  • Microglia
  • Neuroinflammation
  • Neurotoxicity
  • Propofol

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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