Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release

Jianhui Liu; Yuju Li; Xiaohuan Xia; Xiaoyu Yang; Runze Zhao; Justin Peer; Hongyun Wang; Zenghan Tong; Fengtong Gao; Hai Lin; Beiqing Wu; Yunlong Huang; Jialin C. Zheng

doi:10.1016/j.jneuroim.2019.05.003

Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release

Jianhui Liu, Yuju Li, Xiaohuan Xia, Xiaoyu Yang, Runze Zhao, Justin Peer, Hongyun Wang, Zenghan Tong, Fengtong Gao, Hai Lin, Beiqing Wu, Yunlong Huang, Jialin C. Zheng

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Propofol is an established anesthetic widely used for induction and maintenance of anesthesia. We investigated propofol for its anti-inflammatory effects on microglia and found that propofol treatment is associated with substantial lower levels of extracellular vesicles (EVs) in immune activated microglia. Importantly, EVs collected from immune activated microglia reversed propofol-mediated anti-inflammatory and neuroprotective effects, suggesting that propofol reduces proinflammatory microglia activation and microglia-mediated neurotoxicity through inhibition of EV release. These data shed new insight into a novel molecular mechanism of propofol-mediated neuroprotective and immunomodulatory effects through inhibition of EV release.

Original language	French
Article number	476962
Journal	Journal of Neuroimmunology
Volume	333
DOIs	https://doi.org/10.1016/j.jneuroim.2019.05.003
State	Published - Aug 15 2019

Keywords

Anesthetics
Extracellular vesicles
Microglia
Neuroinflammation
Neurotoxicity
Propofol

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2019.05.003

Cite this

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title = "Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release",

abstract = "Propofol is an established anesthetic widely used for induction and maintenance of anesthesia. We investigated propofol for its anti-inflammatory effects on microglia and found that propofol treatment is associated with substantial lower levels of extracellular vesicles (EVs) in immune activated microglia. Importantly, EVs collected from immune activated microglia reversed propofol-mediated anti-inflammatory and neuroprotective effects, suggesting that propofol reduces proinflammatory microglia activation and microglia-mediated neurotoxicity through inhibition of EV release. These data shed new insight into a novel molecular mechanism of propofol-mediated neuroprotective and immunomodulatory effects through inhibition of EV release.",

keywords = "Anesthetics, Extracellular vesicles, Microglia, Neuroinflammation, Neurotoxicity, Propofol",

author = "Jianhui Liu and Yuju Li and Xiaohuan Xia and Xiaoyu Yang and Runze Zhao and Justin Peer and Hongyun Wang and Zenghan Tong and Fengtong Gao and Hai Lin and Beiqing Wu and Yunlong Huang and Zheng, {Jialin C.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = aug,

day = "15",

doi = "10.1016/j.jneuroim.2019.05.003",

language = "French",

volume = "333",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release

AU - Liu, Jianhui

AU - Li, Yuju

AU - Xia, Xiaohuan

AU - Yang, Xiaoyu

AU - Zhao, Runze

AU - Peer, Justin

AU - Wang, Hongyun

AU - Tong, Zenghan

AU - Gao, Fengtong

AU - Lin, Hai

AU - Wu, Beiqing

AU - Huang, Yunlong

AU - Zheng, Jialin C.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Propofol is an established anesthetic widely used for induction and maintenance of anesthesia. We investigated propofol for its anti-inflammatory effects on microglia and found that propofol treatment is associated with substantial lower levels of extracellular vesicles (EVs) in immune activated microglia. Importantly, EVs collected from immune activated microglia reversed propofol-mediated anti-inflammatory and neuroprotective effects, suggesting that propofol reduces proinflammatory microglia activation and microglia-mediated neurotoxicity through inhibition of EV release. These data shed new insight into a novel molecular mechanism of propofol-mediated neuroprotective and immunomodulatory effects through inhibition of EV release.

AB - Propofol is an established anesthetic widely used for induction and maintenance of anesthesia. We investigated propofol for its anti-inflammatory effects on microglia and found that propofol treatment is associated with substantial lower levels of extracellular vesicles (EVs) in immune activated microglia. Importantly, EVs collected from immune activated microglia reversed propofol-mediated anti-inflammatory and neuroprotective effects, suggesting that propofol reduces proinflammatory microglia activation and microglia-mediated neurotoxicity through inhibition of EV release. These data shed new insight into a novel molecular mechanism of propofol-mediated neuroprotective and immunomodulatory effects through inhibition of EV release.

KW - Anesthetics

KW - Extracellular vesicles

KW - Microglia

KW - Neuroinflammation

KW - Neurotoxicity

KW - Propofol

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DO - 10.1016/j.jneuroim.2019.05.003

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AN - SCOPUS:85065733881

SN - 0165-5728

VL - 333

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 476962

ER -

Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release

Abstract

Keywords

ASJC Scopus subject areas

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