TY - JOUR
T1 - Prospective native coronary artery stenosis treated with sirolimus-eluting stent (ONASSIS) registry - Acute results and mid-term outcomes
T2 - A single-center experience
AU - Voudris, Vassilis
AU - Alexopoulos, Elias
AU - Karyofillis, Panagiotis
AU - Malakos, John
AU - Manginas, Athanasios
AU - Spargias, Constantinos
AU - Pavlides, Gregory
AU - Patsilinakos, Sotirios
AU - Anyfantakis, Alexandros
AU - Cokkinos, Dennis V.
PY - 2005/8
Y1 - 2005/8
N2 - Background. Encouraging results with the use of the sirolimus-eluting stent (SES) have been recently presented in several multicenter trials. In the present study, the short-and mid-term clinical outcomes of the SES in everyday clinical practice of interventional cardiology were compared with a strategy using conventional bare metal stents. Methods. In a total of 530 consecutive patients (males 86%, mean age 61 ± 10 years) who had been treated with a SES were compared with a control group of 398 patients (males 87%, mean age 59 ± 11 years) treated with a bare metal stent before the use of SES. In-hospital results and clinical outcomes during follow-up (11.22 ± 3.4 versus 11.41 ± 3.1 months) were obtained. Results. Patients treated with SES had more risk factors for coronary artery disease or multivessel disease compared to those with treated bare metal stent. The clinical success rate was 99.6% in the SES group and 98.5% in the bare metal stent group (p = ns), and non-Q-wave myocardial infarction (MI) occurred in 5.7% and 4.0% of patients, respectively. The incidence of death or MI during follow-up was not different (1.1% versus 1.3% and 0.8% versus 1.8%; p = ns). Percutaneous or surgical revascularization for target lesion restenosis was required in 2.1% of patients treated with SES and in 10.1% of those with bare metal stents (p < 0.001), and the event-free survival from death, cerebrovascular accident, MI or any percutaneous or surgical revascularization was 93.13% and 83.63%, respectively (p < 0.01). Conclusions. The implantation of the SES is associated with excellent in-hospital and mid-term results, mainly because of dramatic reductions in the need for repeat revascularization, despite a higher risk factor profile and more complex lesion characteristics.
AB - Background. Encouraging results with the use of the sirolimus-eluting stent (SES) have been recently presented in several multicenter trials. In the present study, the short-and mid-term clinical outcomes of the SES in everyday clinical practice of interventional cardiology were compared with a strategy using conventional bare metal stents. Methods. In a total of 530 consecutive patients (males 86%, mean age 61 ± 10 years) who had been treated with a SES were compared with a control group of 398 patients (males 87%, mean age 59 ± 11 years) treated with a bare metal stent before the use of SES. In-hospital results and clinical outcomes during follow-up (11.22 ± 3.4 versus 11.41 ± 3.1 months) were obtained. Results. Patients treated with SES had more risk factors for coronary artery disease or multivessel disease compared to those with treated bare metal stent. The clinical success rate was 99.6% in the SES group and 98.5% in the bare metal stent group (p = ns), and non-Q-wave myocardial infarction (MI) occurred in 5.7% and 4.0% of patients, respectively. The incidence of death or MI during follow-up was not different (1.1% versus 1.3% and 0.8% versus 1.8%; p = ns). Percutaneous or surgical revascularization for target lesion restenosis was required in 2.1% of patients treated with SES and in 10.1% of those with bare metal stents (p < 0.001), and the event-free survival from death, cerebrovascular accident, MI or any percutaneous or surgical revascularization was 93.13% and 83.63%, respectively (p < 0.01). Conclusions. The implantation of the SES is associated with excellent in-hospital and mid-term results, mainly because of dramatic reductions in the need for repeat revascularization, despite a higher risk factor profile and more complex lesion characteristics.
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M3 - Article
C2 - 16079443
AN - SCOPUS:25144498734
SN - 1042-3931
VL - 17
SP - 401
EP - 405
JO - Journal of Invasive Cardiology
JF - Journal of Invasive Cardiology
IS - 8
ER -