Prospective one-year study of ranibizumab for predominantly hemorrhagic choroidal neovascular lesions in age-related macular degeneration

Margaret A. Chang, Diana V. Do, Susan B. Bressler, Sandra D. Cassard, Emily W. Gower, Neil M. Bressler

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Purpose: To determine the safety and effect of ranibizumab on predominantly hemorrhagic choroidal neovascular lesions due to age-related macular degeneration. Methods: Seven subjects with predominantly hemorrhagic choroidal neovascular lesions were treated with intravitreal injections of ranibizumab at baseline, Month 1, and Month 2. Additional monthly injections were given through Month 11 at the discretion of the examiner for a potential maximum of 12 injections. Results: At 12 months, the median visual acuity letter score was 30 (Snellen equivalent: 20/250), with a median change from baseline to last follow-up of +7 letters. Three of 7 subjects (43%) gained 2 or more lines of vision, while no subject lost 2 or more lines. The median change in OCT central subfield thickness from baseline to Month 12 was -109 μm, with a mean of -120 ± 158 μm. Two eyes had retinal pigment epithelial tears. No ocular adverse events or systemic adverse events were reported related to the usage of ranibizumab. Conclusion: With no subject losing 2 or more lines of visual acuity over 12 months and no new safety concerns identified, these predominantly hemorrhagic lesions treated with ranibizumab appeared to have a better visual acuity outcome than the natural history controls of the submacular surgery trials. While the study is limited by few cases enrolled, the results suggest that ranibizumab is able to penetrate through the subretinal hemorrhage to affect the underlying hemorrhagic choroidal neovascular lesion and the natural history.

Original languageEnglish (US)
Pages (from-to)1171-1176
Number of pages6
JournalRetina
Volume30
Issue number8
DOIs
StatePublished - Sep 2010

Keywords

  • age-related macular degeneration
  • choroidal neovascularization
  • hemorrhagic
  • ranibizumab

ASJC Scopus subject areas

  • Ophthalmology

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