TY - JOUR
T1 - Prostacyclin, thromboxane A2, and atherosclerosis in young hypercholesterolemic swine
AU - Norman, J. F.
AU - Miller, C. W.
N1 - Funding Information:
This study was funded by a Biomedical Research Support Grant from the College of Veterinary Medicine and Biomedical Sciences at Colorado State University, Fort Collins, CO, USA.
PY - 1994/10
Y1 - 1994/10
N2 - Plasma 6-keto-prostaglandin F1α and thromboxane B2 levels were determined to evaluate their role as predictive indicators for the development and progression of coronary atherosclerosis in young hypercholesterolemic swine. 32 young swine were randomly assigned to the control or atherogenic diet group for 10, 30, 90, or 180 days. Lipid profiles were obtained at the onset and repeated throughout the study. Radioimmunoassays of plasma 6-keto-prostaglandin F1α and thromboxane B2 were recorded at 10 day intervals in the 10 and 30 day subjects and at 30 day intervals in the 90 and 180 day subjects. Sections from the proximal left anterior descending coronary artery were classified based on their histological evidence of atherosclerosis by light microscopy. Hypercholesterolemia was positively correlated with development of coronary atherosclerosis (r = 0.704). However, plasma 6-keto-prostaglandin F1α, thromboxane B2, and the thromboxane B2:6-keto-prostaglandin F1α ratio were not found to be predictive indicators (p > 0.05) for the development or early progression of coronary atherosclerosis.
AB - Plasma 6-keto-prostaglandin F1α and thromboxane B2 levels were determined to evaluate their role as predictive indicators for the development and progression of coronary atherosclerosis in young hypercholesterolemic swine. 32 young swine were randomly assigned to the control or atherogenic diet group for 10, 30, 90, or 180 days. Lipid profiles were obtained at the onset and repeated throughout the study. Radioimmunoassays of plasma 6-keto-prostaglandin F1α and thromboxane B2 were recorded at 10 day intervals in the 10 and 30 day subjects and at 30 day intervals in the 90 and 180 day subjects. Sections from the proximal left anterior descending coronary artery were classified based on their histological evidence of atherosclerosis by light microscopy. Hypercholesterolemia was positively correlated with development of coronary atherosclerosis (r = 0.704). However, plasma 6-keto-prostaglandin F1α, thromboxane B2, and the thromboxane B2:6-keto-prostaglandin F1α ratio were not found to be predictive indicators (p > 0.05) for the development or early progression of coronary atherosclerosis.
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U2 - 10.1016/0952-3278(94)90194-5
DO - 10.1016/0952-3278(94)90194-5
M3 - Article
C2 - 7846098
AN - SCOPUS:0028169186
SN - 0952-3278
VL - 51
SP - 293
EP - 298
JO - Prostaglandins, Leukotrienes and Essential Fatty Acids
JF - Prostaglandins, Leukotrienes and Essential Fatty Acids
IS - 4
ER -