Prostacyclin, thromboxane A2, and atherosclerosis in young hypercholesterolemic swine

J. F. Norman, C. W. Miller

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Plasma 6-keto-prostaglandin F and thromboxane B2 levels were determined to evaluate their role as predictive indicators for the development and progression of coronary atherosclerosis in young hypercholesterolemic swine. 32 young swine were randomly assigned to the control or atherogenic diet group for 10, 30, 90, or 180 days. Lipid profiles were obtained at the onset and repeated throughout the study. Radioimmunoassays of plasma 6-keto-prostaglandin F and thromboxane B2 were recorded at 10 day intervals in the 10 and 30 day subjects and at 30 day intervals in the 90 and 180 day subjects. Sections from the proximal left anterior descending coronary artery were classified based on their histological evidence of atherosclerosis by light microscopy. Hypercholesterolemia was positively correlated with development of coronary atherosclerosis (r = 0.704). However, plasma 6-keto-prostaglandin F, thromboxane B2, and the thromboxane B2:6-keto-prostaglandin F ratio were not found to be predictive indicators (p > 0.05) for the development or early progression of coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume51
Issue number4
DOIs
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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