Proteases as modulators of tumor-stromal interaction: Primary tumors to bone metastases

Thomas J. Wilson, Rakesh K. Singh

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

As cells undergo oncogenic transformation and as malignant cells arrive at metastatic sites, a complex interplay occurs with the surrounding stroma. This dialogue between the tumor and stroma ultimately dictates the success of the tumor cells in the given microenvironment. As a result, understanding the molecular mechanisms at work is important for developing new therapeutic modalities. Proteases are major players in the interaction between tumor and stroma. This review will focus on the role of proteases in modulating tumor-stromal interactions of both primary breast and prostate tumors as well as at bone metastatic sites in a way that favors tumor growth.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1785
Issue number2
DOIs
StatePublished - Apr 2008

Keywords

  • Bone metastasis
  • Proteases
  • Tumor progression
  • Tumor-stromal interaction

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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