A single intraperitoneal dose of carbon tetrachloride (CCl4), from 0.004 to 0.5 ml/kg, protected male mice against the toxic effects of dimethylnitrosamine (DMN). The LD50 of DMN was increased by a factor of about 4.2 with the highest dose of CCl4 and by a lesser factor with lower doses. The increase in LD50 correlated with a decrease in DMN demethylase activity in the liver of CCl4 treated mice. These effects commenced within 10 min of administration of CCl4 increased very rapidly for 12 hr to a high level which was maintained for up to 60 hr after which the LD50 of DMN and the level of DMN demethylase returned slowly to normal only in 5 or 6 days. The administration of CCl4 reduced the acute hepatonecrotic action of DMN.
|Number of pages
|British Journal of Experimental Pathology
|Published - 1975
ASJC Scopus subject areas
- Pathology and Forensic Medicine