Protein phosphatase 2Cα expression in normal human tissues: An immunohistochemical study

Beatriz Lifschitz-Mercer, Yuri Sheinin, Daniella Ben-Meir, Letizia Bramante-Schreiber, Leonor Leider-Trejo, Shulamit Karby, Nechama I. Smorodinsky, Sara Lavi

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Protein phosphatase (PP2Cα) is a member of the mammalian serine threonine-specific protein phosphatases family. We produced monoclonal antibodies against the recombinant PP2Cα and evaluated the immunoreactivity of normal human tissues. The reactivity was strong in normal skin, the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, while it was moderate in the ovary, testis, and liver. Epithelial cells revealed high levels of PP2Cα expression, but stromal cells, including fibroblasts and endothelial cells, showed no or little PP2Cα expression. Given the broad reactivity in endocrine and secreting epithelial cells, we propose that PP2Cα expression might contribute to secretory cell function.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalHistochemistry and Cell Biology
Volume116
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Histology
  • Human
  • Immunohistochemistry
  • Protein phosphatase 2Cα
  • Tissue distribution

ASJC Scopus subject areas

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

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