Protein quality control and degradation in cardiomyocytes

Xuejun Wang; Huabo Su; Mark J. Ranek

doi:10.1016/j.yjmcc.2008.03.025

Protein quality control and degradation in cardiomyocytes

Xuejun Wang, Huabo Su, Mark J. Ranek

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure.

Original language	English (US)
Pages (from-to)	11-27
Number of pages	17
Journal	Journal of Molecular and Cellular Cardiology
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.yjmcc.2008.03.025
State	Published - Jul 2008
Externally published	Yes

Keywords

Autophagy
Chaperones
Proteases
Proteasome
Signal transduction
Ubiquitin

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/j.yjmcc.2008.03.025

Cite this

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title = "Protein quality control and degradation in cardiomyocytes",

abstract = "The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure.",

keywords = "Autophagy, Chaperones, Proteases, Proteasome, Signal transduction, Ubiquitin",

author = "Xuejun Wang and Huabo Su and Ranek, {Mark J.}",

note = "Funding Information: Dr. X. Wang is an Established Investigator of American Heart Association (AHA). Research work in Dr. Wang's laboratory is currently supported by the MD/PhD Program of Sanford School of Medicine of the University of South Dakota as well as by grants R01HL072166 and R01HL085629 from the National Heart, Lung, and Blood Institute/NIH and grant 0740025N from AHA (to X. W.). Dr. H. Su is supported by an AHA postdoctoral fellowship (0625738Z).",

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AU - Ranek, Mark J.

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N2 - The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure.

AB - The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure.

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KW - Chaperones

KW - Proteases

KW - Proteasome

KW - Signal transduction

KW - Ubiquitin

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Protein quality control and degradation in cardiomyocytes

Abstract

Keywords

ASJC Scopus subject areas

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