Proteolytic regulation of mitochondrial dynamics

Jonathan V. Dietz, Iryna Bohovych, Martonio Ponte Viana, Oleh Khalimonchuk

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Spatiotemporal changes in the abundance, shape, and cellular localization of the mitochondrial network, also known as mitochondrial dynamics, are now widely recognized to play a key role in mitochondrial and cellular physiology as well as disease states. This process involves coordinated remodeling of the outer and inner mitochondrial membranes by conserved dynamin-like guanosine triphosphatases and their partner molecules in response to various physiological and stress stimuli. Although the core machineries that mediate fusion and partitioning of the mitochondrial network have been extensively characterized, many aspects of their function and regulation are incompletely understood and only beginning to emerge. In the present review we briefly summarize current knowledge about how the key mitochondrial dynamics-mediating factors are regulated via selective proteolysis by mitochondrial and cellular proteolytic machineries.

Original languageEnglish (US)
Pages (from-to)289-304
Number of pages16
JournalMitochondrion
Volume49
DOIs
StatePublished - Nov 2019

Keywords

  • GTPases
  • Mitochondria
  • Mitochondrial dynamics
  • Proteolysis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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