Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders

Gurudutt Pendyala; Howard S. Fox

doi:10.1186/gm143

Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders

Gurudutt Pendyala, Howard S. Fox

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Diagnosing neurodegenerative diseases, monitoring their progression and assessing responses to treatments will all be aided by the identification of molecular markers of different stages of pathology. Protein biomarkers for HIV-associated neurocognitive disorders that have been discovered using proteomics include complement C3, soluble superoxide dismutase and a prostaglandin synthase. Metabolomics has not yet been widely used for biomarker discovery, but early work shows that it has great potential.

Original language	English (US)
Article number	1756
Journal	Genome Medicine
Volume	2
Issue number	3
DOIs	https://doi.org/10.1186/gm143
State	Published - Mar 30 2010

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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10.1186/gm143

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abstract = "Diagnosing neurodegenerative diseases, monitoring their progression and assessing responses to treatments will all be aided by the identification of molecular markers of different stages of pathology. Protein biomarkers for HIV-associated neurocognitive disorders that have been discovered using proteomics include complement C3, soluble superoxide dismutase and a prostaglandin synthase. Metabolomics has not yet been widely used for biomarker discovery, but early work shows that it has great potential.",

author = "Gurudutt Pendyala and Fox, {Howard S.}",

note = "Funding Information: This is manuscript #08 from the UNMC Center for Integrative and Translational Neuroscience. Our work is supported by NIH grants P30 MH062261, R01 MH073490 and P01 DA026146. We thank Robin Taylor (UNMC) for editing assistance.",

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N2 - Diagnosing neurodegenerative diseases, monitoring their progression and assessing responses to treatments will all be aided by the identification of molecular markers of different stages of pathology. Protein biomarkers for HIV-associated neurocognitive disorders that have been discovered using proteomics include complement C3, soluble superoxide dismutase and a prostaglandin synthase. Metabolomics has not yet been widely used for biomarker discovery, but early work shows that it has great potential.

AB - Diagnosing neurodegenerative diseases, monitoring their progression and assessing responses to treatments will all be aided by the identification of molecular markers of different stages of pathology. Protein biomarkers for HIV-associated neurocognitive disorders that have been discovered using proteomics include complement C3, soluble superoxide dismutase and a prostaglandin synthase. Metabolomics has not yet been widely used for biomarker discovery, but early work shows that it has great potential.

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Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders

Abstract

ASJC Scopus subject areas

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