Proteomics and genomics

Wojciech Rozek; Pawel S. Ciborowski

doi:10.1007/978-0-387-72573-4_49

Proteomics and genomics

Wojciech Rozek, Pawel S. Ciborowski

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Successful completion of sequencing of the human genome showed considerably smaller number of genes (20,000 to 25,000 protein coding genes) (International Human Genome Sequencing Consortium. Lander ES, 2004) than expected and the number of proteins greatly exceeding the number of genes. This had a big impact on how we envision human and other proteomes and how we will approach proteomic and genomic analyses in the future. Isoforms, products of one gene modified by posttranslational modifications or alternative splicing, is only one part of complexity because function and biological role can also depend on cytoplasmic, subcellular compartments, and/or extracellular localization. Interactions with other proteins and nonproteinacious molecules add yet another layer of complexity.

Original language	English (US)
Title of host publication	Neuroimmune Pharmacology
Publisher	Springer US
Pages	725-741
Number of pages	17
ISBN (Print)	9780387725727
DOIs	https://doi.org/10.1007/978-0-387-72573-4_49
State	Published - 2008

Keywords

2 dimensional electrophoresis
Bioinformatics
Biomarker
Genomics
Neuroproteomics
Protein fi ngerprinting
Protein profi ling
Proteomics
Systems biology
Tissue profi ling

ASJC Scopus subject areas

General Neuroscience
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/978-0-387-72573-4_49

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AU - Ciborowski, Pawel S.

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KW - Biomarker

KW - Genomics

KW - Neuroproteomics

KW - Protein fi ngerprinting

KW - Protein profi ling

KW - Proteomics

KW - Systems biology

KW - Tissue profi ling

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Proteomics and genomics

Abstract

Keywords

ASJC Scopus subject areas

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