Proteomics, biomarkers, and HIV-1: A current perspective

Maire Rose Donnelly, Pawel Ciborowski

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Despite more than three decades of extensive research, HIV-1 infection although well controlled with cART, remains incurable. Multifactorial complexity of the viral life-cycle poses great challenges in understanding molecular mechanisms underlying this infection and the development of biomarkers, which we hope will lead us to its eradication. For a more in-depth understanding of how the virus interacts with host target cells, T cells and macrophages, proteomic profiling techniques that offer strategies to investigate the proteome in its entirety were employed. Here, we review proteomic studies related to HIV-1 infection and discuss perspectives and limitations of proteomic and systems biology approaches in future studies.

Original languageEnglish (US)
Pages (from-to)110-125
Number of pages16
JournalProteomics - Clinical Applications
Volume10
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • Biomarker
  • Body fluids
  • HIV
  • Macrophage
  • Systems biology
  • T cell

ASJC Scopus subject areas

  • Clinical Biochemistry

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