Abstract
Despite more than three decades of extensive research, HIV-1 infection although well controlled with cART, remains incurable. Multifactorial complexity of the viral life-cycle poses great challenges in understanding molecular mechanisms underlying this infection and the development of biomarkers, which we hope will lead us to its eradication. For a more in-depth understanding of how the virus interacts with host target cells, T cells and macrophages, proteomic profiling techniques that offer strategies to investigate the proteome in its entirety were employed. Here, we review proteomic studies related to HIV-1 infection and discuss perspectives and limitations of proteomic and systems biology approaches in future studies.
Original language | English (US) |
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Pages (from-to) | 110-125 |
Number of pages | 16 |
Journal | Proteomics - Clinical Applications |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2016 |
Keywords
- Biomarker
- Body fluids
- HIV
- Macrophage
- Systems biology
- T cell
ASJC Scopus subject areas
- Clinical Biochemistry