ProTide generated long-acting abacavir nanoformulations

Zhiyi Lin, Nagsen Gautam, Yazen Alnouti, Joellyn McMillan, Aditya N. Bade, Howard E. Gendelman, Benson Edagwa

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

Original languageEnglish (US)
Pages (from-to)8371-8374
Number of pages4
JournalChemical Communications
Volume54
Issue number60
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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