TY - JOUR
T1 - Proton Magnetic Resonance Spectroscopy in Multiple Sclerosis
AU - Sajja, Balasrinivasa R.
AU - Wolinsky, Jerry S.
AU - Narayana, Ponnada A.
N1 - Funding Information:
This work was supported in part by NIH/NIBIB Grant No. EB02095.
PY - 2009/2
Y1 - 2009/2
N2 - Proton magnetic resonance spectroscopy (1H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathologic changes in multiple sclerosis (MS). In addition, the role of MRS in objectively evaluating therapeutic efficacy is reviewed. This potential metabolic information makes MRS a unique tool to follow MS disease evolution, understand its pathogenesis, evaluate the disease severity, establish a prognosis, and objectively evaluate the efficacy of therapeutic interventions.
AB - Proton magnetic resonance spectroscopy (1H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathologic changes in multiple sclerosis (MS). In addition, the role of MRS in objectively evaluating therapeutic efficacy is reviewed. This potential metabolic information makes MRS a unique tool to follow MS disease evolution, understand its pathogenesis, evaluate the disease severity, establish a prognosis, and objectively evaluate the efficacy of therapeutic interventions.
KW - Brain metabolites
KW - Multiple sclerosis
KW - Proton magnetic resonance spectroscopy
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U2 - 10.1016/j.nic.2008.08.002
DO - 10.1016/j.nic.2008.08.002
M3 - Review article
C2 - 19064199
AN - SCOPUS:57049160388
SN - 1052-5149
VL - 19
SP - 45
EP - 58
JO - Neuroimaging Clinics of North America
JF - Neuroimaging Clinics of North America
IS - 1
ER -