Proton Magnetic Resonance Spectroscopy in Multiple Sclerosis

Balasrinivasa R. Sajja, Jerry S. Wolinsky, Ponnada A. Narayana

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations

Abstract

Proton magnetic resonance spectroscopy (1H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathologic changes in multiple sclerosis (MS). In addition, the role of MRS in objectively evaluating therapeutic efficacy is reviewed. This potential metabolic information makes MRS a unique tool to follow MS disease evolution, understand its pathogenesis, evaluate the disease severity, establish a prognosis, and objectively evaluate the efficacy of therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)45-58
Number of pages14
JournalNeuroimaging Clinics of North America
Volume19
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • Brain metabolites
  • Multiple sclerosis
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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