Proton spectroscopy of brain glutamine in acute liver failure

James R. McConnell; Dean L. Antonson; Chin Siong Ong; Wei Kom Chu; Ira J. Fox; Thomas G. Heffron; Alan N. Langnas; Byers W. Shaw

doi:10.1016/0270-9139(95)90354-2

Proton spectroscopy of brain glutamine in acute liver failure

James R. McConnell, Dean L. Antonson, Chin Siong Ong, Wei Kom Chu, Ira J. Fox, Thomas G. Heffron, Alan N. Langnas, Byers W. Shaw

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59 Scopus citations

Abstract

Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (¹H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha ¹H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF.

Original language	English (US)
Pages (from-to)	69-74
Number of pages	6
Journal	Hepatology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/0270-9139(95)90354-2
State	Published - Jul 1995

ASJC Scopus subject areas

Hepatology

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title = "Proton spectroscopy of brain glutamine in acute liver failure",

abstract = "Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (1H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha 1H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF.",

author = "McConnell, {James R.} and Antonson, {Dean L.} and Ong, {Chin Siong} and Chu, {Wei Kom} and Fox, {Ira J.} and Heffron, {Thomas G.} and Langnas, {Alan N.} and Shaw, {Byers W.}",

year = "1995",

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T1 - Proton spectroscopy of brain glutamine in acute liver failure

AU - McConnell, James R.

AU - Antonson, Dean L.

AU - Ong, Chin Siong

AU - Chu, Wei Kom

AU - Fox, Ira J.

AU - Heffron, Thomas G.

AU - Langnas, Alan N.

AU - Shaw, Byers W.

PY - 1995/7

Y1 - 1995/7

N2 - Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (1H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha 1H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF.

AB - Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (1H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha 1H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF.

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Proton spectroscopy of brain glutamine in acute liver failure

Abstract

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